The following documents are clinical guidance for healthcare professionals.  If you are looking for studies supporting early COVID-19 treatments, click here.

Outpatient Targeted Sequential Multidrug Treatment

McCullough P et al. “Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19).” Reviews in Cardiovascular Medicine, 2020, 21(4): 517-530. Doi: 10.31083/j.rcm.2020.04.264

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Summary: The decisive guidance for outpatient treatment, offering flexible options for targeted interventions with multiple drugs including hydroxychloroquine, ivermectin, azithromycin, doxycycline, corticosteroids, and nutritional supplements.

Alexander P et al. “Early Multidrug Outpatient Treatment of SARS-CoV-2 Infection (COVID-19) and Reduced Mortality Among Nursing Home Residents.” Medical Hypotheses, vol 153, August 2021, 110622. Doi: 10.1016/j.mehy.2021.110622

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Summary: Early outpatient ambulatory treatment, once initiated as soon as symptoms begin in high-risk positive persons, would significantly reduce hospitalizations and prevent deaths. Specifically, the provision of early multi-drug sequenced therapy with repurposed drugs will reduce hospitalization and death in elderly patients being cared for in long-term-care facilities.


Hydroxychloroquine: Zelenko Treatment and PrEP Protocols

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Download PDF: PrEP

Summary: The pioneering protocols developed by Dr. Vladimir “Zev” Zelenko, combining hydroxychloroquine and zinc with a variety of other drugs. Now updated by Dr. Zelenko to also include ivermectin per our evolving understanding of COVID-19 disease. 


Ivermectin: I-MASK+ Protocol, MATH+ Protocol

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Download PDF: MATH+

Summary: Developed by the Front Line COVID-19 Critical Care Alliance (FLCCC), the I-MASK+ protocol focuses on ivermectin for outpatient treatment and PrEP, while the MATH+ protocol provides guidance for the use of ivermectin for treatment of hospitalized patients.  


Budesonide: Dosing Guidance, Budesonide Protocol

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Download PDF: Portuguese translation

Summary: This guidance was developed by the Early COVID Care Experts based on the Oxford STOIC study findings.


Vaccine Side Effects: OTC Medicines and Nutritional Supplements to Reduce Post-Vaccination Side Effects

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Summary: These recommendations are based on the clinical experience of COVID-expert doctors surveyed.